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Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.

Compounders were expected to cease production of tirzepatide by March 2025 and semaglutide by May 2025, yet both remain active in the market

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Here, we confirm that neither Epsin nor the cytosolic domains of DSL proteins are required for Notch signaling in C