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It has been suggested that GLP-1 secretion is mediated by other intracellular pathways such as extracellular signal-regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK) and p38 MAPK, activated by peptones and mixtures of essential amino acids in NCI-H716 cells (Reference Reimer82)

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Klobuar, S., Belani, A., Buka, I., Mori, N., & Raheli, D

For efficient knockdown of the TGF- and DPP4 genes, pooled siRNAs (siRNA1 and siRNA2) targeting each gene were used