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In a once-daily multiple ascending dose phase Ib clinical trial and a 41-day phase IIa trial in overweight and type 2 diabetic patients, general safety and tolerability of MEDI0382 were established, as well as placebo-corrected efficacy in reducing fasting blood glucose (1.7 mmol/L), post-prandial glucose excursions following a mixed meal test (22.6% AUC 04 h ), body weight (2.1 kg), and liver fat (19.6%) [7]

Pediatr Res 99 , 416417 (2026)

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PLoS ONE 9(6):e101005 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M et al (2010) GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

Diabetologia 65(Suppl 1):S288S288 Samms RJ, Zhang G, He W et al (2022) Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue