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Appetite drops on Ozempic, Wegovy, and Zepbound, but nutrition needs remain

Semaglutide produces significant weight loss for many patients, but individual results vary widely based on genetics, metabolism, and lifestyle

Switching to the oral small molecule glucagon-like peptide-1 (GLP-1) orforglipron after taking injectable GLP-1s helped patients maintain mostbut not allof their weight loss, according to a clinical trial led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

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The combinations of DPP-4 inhibitors with metformin and/or sodium-glucose transport protein-2 inhibitors are rationalized in this paper, considering their complementary mechanisms of action
