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A review of 30 randomized controlled trials that included 1,736 people with type 2 diabetes or non-alcoholic fatty liver disease found that treatment with GLP-1 agonists significantly reduced both visceral and liver fat

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In the phase 2 trial, participants started at 4 mg without escalation experienced significantly more adverse events than those who began at 2 mg

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10.1038/tpj.2015.59 227

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Vadim Sherman of Houston Methodist described the access gap clearly: "Widespread adoption is still an issue, mostly due to insurance coverage and cost." CMS Administrator Dr

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Retatrutide remains investigational

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The estimated treatment difference was 8.03%, and higher than the weight change difference in the non-bariatric patients treated with liraglutide, which had been reported as 4.8% in a recent systematic review and meta-analysis of randomized controlled trials [50]

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