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At Week 52, 26% of patients randomized to insulin degludec achieved the fasting serum glucose target of 50 ng/L

Last reviewed: June 6, 2026 Last updated: June 6, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

This is the reason why getting your 10-unit conversion right is not just an academic exercise

Tolerance indicators are equally important in determining readiness for dose advancement

The FDA prescribing information for Mounjaro and Zepbound does not highlight arthralgia as a common adverse reaction, and joint inflammation is not identified as a known pharmacologic effect of GIP or GLP-1 receptor activation

Users at higher doses ( 10-15 mg ) who have addressed meal timing, GI management, and sleep hygiene typically report sleep quality that is equal to or better than pre-treatment, especially if they have lost significant weight and had any degree of sleep apnea before starting