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Key data point: in the retatrutide fatty-liver study, Sanyal and colleagues (Nature Medicine, 2024) reported liver fat falling 80 to 90 percent over 48 weeks in patients who started with fatty liver disease, a drop tied closely to the weight and belly-fat loss and, in theory, to glucagon-receptor-driven fat burning in the liver

These findings suggest that the effectiveness of oral semaglutide in reducing HbA1c levels was preserved in individuals who took the drug at times other than the morning fast, provided that a pre- and post-dose fasting was respected

We do month visits where we gradually increase the dose, Dr

Of note, both drugs achieved very favorable effects on lipids, reducing triglycerides, LDL and raising HDL cholesterol, along with reduction of blood pressure, an outgrowth of the indirect effect of weight reduction and direct metabolic effects of the drugs