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Coverage differs by diagnosis

They are pushing for additional discovery and bellwether trials, aiming to investigate and resolve these cases thoroughly

Mean follow-up duration was 3.4 years (IQR = 0-4.5 years)

Keywords: GLP-1RA, Model-based meta-analysis, Obesity, Weight reduction Graphical abstract Highlights Offers a detailed comparison of the efficacy, potential influencing factors and safety profiles among various GLP-1RAs

HbA1c Reduction observed: Orforglipron 3 mg dose: 1.3% decrease Orforglipron 12 mg dose: 1.6% decrease Orforglipron 36 mg dose: 1.5% decrease Placebo: 0.1% decrease Orforglipron compared to placebo resulted in a significant reduction in HbA1c at all tested doses

GLP-1s on their own have a low risk of hypoglycemia