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Studies in Glp2r / mice revealed that GLP-2R was required for jejunal villi length expansion upon cold stress

Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, Chandramouli V, Rungby J, Landau BR, Schmitz O

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but exogenous estrogen replacement in post-menopausal women was found to have several adverse side effects, therefore this treatment is not recommended (Rajfer et al