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Unlike injectable GLP-1s, orforglipron is a once-daily oral agent, offering an alternative for patients averse to injections

This loss of lean body mass was substantially attenuated when endurance (cardiovascular) exercise was added to the weight loss program

Thus, SGLT2i have become a mainstay of chronic kidney disease (CKD) and congestive heart failure treatment

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doi: 10.3390/ijms22105303, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 105.Donnelly D

Diabetes Therapy 11(1):3752