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The root causes of metabolic dysfunction must also be addressed for sustainable results. The Guts Role in Metabolic Health A key element of sustainable care lies in optimizing gut health

Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]

It has been suggested that, centrally, the modulation of anorexigenic proopiomelanocortin (POMC) neurons is responsible for the satiety effects, as they possess GLP-1R and are found in the nucleus of the solitary tract (NTS), a site of GLP-1 production in the brain [35]

Some weight regain during the break is expected and acceptable

While their glucose-lowering effects have been well documented for years, recent clinical breakthroughs have shown that these medications can deliver transformative weight loss, often rivalling or even surpassing results from bariatric surgery for certain patients