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The effects of semaglutide on this panel of plasma proteins are highly informative, suggesting potential benefits that extend beyond HFpEF and warrant further investigation

Both drugs were initially developed for type 2 diabetes and belong to a class known as GLP-1 receptor agonists, which mimic gut hormones to reduce appetite and calorie intake

In contrast to findings with behavioral 20,21,22 and other pharmacological interventions 10,12,13 , the similar mean weight loss achieved with semaglutide 2.4 mg in STEP 5 at weeks 52 and 104 (15.6% and 15.2%, respectively) suggests that, on average, there is minimal weight regain over 104 weeks when once-weekly semaglutide therapy is continued

Glucagon-like peptide 1 (GLP 1) helps to regulate blood sugar levels

GLP-1 drugs seem to work more diffusely, nudging the system rather than cutting off a single route

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