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Most semaglutide users experience nausea and digestive changes that peak within the first 2-4 weeks, then gradually improve over 8-12 weeks as the body adapts to the medication

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While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments

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