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Both are GLP-1 agonists, and tirzepatide involves an additional hormone, known as GIP

Genetics play a role in how your body responds: variants in the GLP1R gene (like rs6923761) influence how sensitive your intestinal cells are to the medication

On the other hand, a series of positive effects have been described in pathways involved in vascular atherogenesis, endothelial function [7, 10] and ventricular contractility [11]

However, for some individuals, fatigue may persist, particularly when other factors, such as dietary changes or underlying health conditions, are contributing

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