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The discovery of the second incretin, GLP-1, originated from observations in 1982 that anglerfish proglucagon mRNA contained coding sequences of glucagon-related peptide, flanked by pairs of basic amino acids characteristic of the sites cleaved during post-translational processing of prohormones (19)

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36 Current evidence suggests a possible link to depressive or suicidal ideation specific to semaglutide 37, and a clearly higher incidence of gastrointestinal adverse events compared with liraglutide.38 Both remain FDA-approved and well-studied

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