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There has been a marked increase in the use of these medications since they were first approved for weight loss in 2014, particularly following the approval of Wegovy in 2021 and Zepbound in 2022

In contrast, GLP-1 alternatives build a long-term foundation for better health through natural GLP-1 activation

Lancet Diabetes Endocrinol 2025;13:196-209.Article 95

GLP1-RAs are very effective for weight reduction

Ongoing research, such as the SUMMIT trial, is presently assessing the safety and efficacy of tirzepatide in HF patients with preserved ejection fraction (HFpEF)

Dipeptidyl peptidase 4 inhibitor use is associated with a lower risk of incident acute kidney injury in patients with diabetes