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Keywords: GLP-1, Exendin-4, food intake, obesity, serotonin Introduction Glucagon-like peptide-1 (GLP-1), a peptide produced in the brain and in the intestine, is a critical regulator of energy balance

Given its complexity, effective obesity management necessitates a multidisciplinary, individualized approach that combines nutritional and behavioral interventions, physical activity, pharmacological therapies, and metabolic-bariatric surgery when indicated

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Phentermine works primarily through stimulation and appetite suppression, while GLP-1 agonists address metabolic signaling and satiety at a hormonal level