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The data suggest theres still headroom for efficacy within existing molecules

When these receptors are stimulated, they reduce the frequency and amplitude of antral contractionsthe muscular waves that normally grind food and push it through the pyloric sphincter into the duodenum

Fan H, Li TF, Gong N, Wang YX (2016) Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis Rotata, reduces neuropathic pain by stimulating spinal microglial beta-endorphin expression

Poly-agonists : Drugs combining GLP-1 with other hormones (GIP, glucagon, amylin) to potentially increase weight loss

doi:10.4088/JCP.14f09572

Recent research has sought to address this gap by developing a new generation of incretin-based medications that simultaneously target multiple metabolic pathways, aiming to improve both metabolic control and downstream organ health