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These effects are usually dose-related and often improve over several weeks

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GLP-1 is rapidly cleaved by the widely expressed dipeptidyl-peptidase-IV (DPP-IV), which removes two N-terminal amino acids, resulting in GLP-1(9-36) with little glucoregulatory properties but with potential cardiovascular effects [18]

Tirzepatide: Tirzepatide targets both the GIP and GLP-1 receptors, providing a synergistic effect that enhances insulin secretion, slows gastric emptying, and reduces appetite

Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes