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CMSs efforts to provide Medicare coverage of GLP-1s for obesity could offer substantial benefits to millions of Medicare beneficiaries, given the high demand for these medications
Under pathological conditions, the disturbances in the balance of leptin and insulin signaling may lead to metabolic disorders, such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, accompanied with insulin resistance and leptin resistance [238], [239], [240]

doi: 10.1160/TH16-07-0586
Its also important to note that binge eating is often a direct result of restrictive eating

"If you increase the dose too quickly, the nausea and other side effects can become much harder to tolerate," he explains

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