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Current evidence limitations include: Lack of transdermal studies : No published randomised controlled trials have specifically evaluated NAD+ patches versus placebo in humans Bioavailability questions : Research has not established whether NAD+ precursors can achieve therapeutically relevant absorption through intact skin Absence of pharmacokinetic data : There are no published studies measuring blood NAD+ levels following patch application Extrapolation concerns : Evidence from oral NAD+ precursors cannot be directly applied to transdermal delivery Some research on oral NAD+ precursors (NR and NMN) has shown modest increases in blood NAD+ levels in small human studies

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