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The primary endpoint was the percentage weight loss at six months (M6) compared to baseline

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The GLP-1 receptor agonists used clinically are based on exendin-4 and native GLP-1 and are available as formulations for daily or weekly s.c

Since that initial phase 2 publication in 2023, the evidence base has expanded substantially

Further studies are needed to investigate the bone impact of GLP-1Ra, dual- and triple-receptor agonists for GLP-1, glucose-dependent insulin releasing polypeptide (GIP), and glucagon in PwO.

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