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Orforglipron, a novel nonpeptide oral daily glucagonlike peptide1 receptor agonist as an antiobesity medicine: A systematic review and metaanalysis

tirzepatide, approved for T2D and undergoing appraisal currently by the National Institute for Health and Care Excellence (NICE) for obesity

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They may include hyper- and hypoglycaemic episodes, blood glucose variability and loss of blood pressure decline

J Clin Endocrinol Metab 102(3):914922