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As a class effect observed with GLP-1 receptor agonists, there are precautionary concerns based on animal studies regarding thyroid C-cell tumours

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Similar relative bioavailability of semaglutide was shown for IcoSema dosing versus semaglutide dosing alone, as the 90% CI for the ratio of total semaglutide exposure after single dose (AUC 0 t ,SD,Semaglutide ) between IcoSema and semaglutide alone was fully contained within the bioequivalence acceptance interval of [0.80;1.25]

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