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Quick Answer: Semaglutide is not metabolized by CYP450 enzymes When starting semaglutide, most clinicians cut the patients mealtime (prandial) insulin dose by 20 to 30% as a starting point, with further adjustments based on glucose monitoring over the first 1 to 2 weeks

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Furthermore, genetic factors and phenotypical interactions can increase metabolic diabetes risk and contribute to the residual -cells that cannot adequately control insulin secretion in the right proportions to overcome the insulin resistance state [37,39,40]

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