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Last reviewed: May 28, 2026 Last updated: May 28, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Fewer GI issues during training GI distress is the most common reason athletes discontinue GLP-1 medications

The components may have natural origins, but the final assembly is human-made

(2013) 5(209):209ra151

In human iPSC-derived dopaminergic neurons from PD patients with SNCA mutations, exendin-4 restored insulin signaling, improved mitochondrial function, and reduced -synuclein aggregation via PI3K/Akt/mTOR activation (26)

Based on current phase 3 TRIUMPH trial timelines, a regulatory submission to the MHRA is not anticipated before 20262027 at the earliest, with a possible marketing authorisation in 20272028 and NHS availability potentially from 2028 onwards, subject to NICE appraisal