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Use of glucagon-like peptide 1 agonists for weight loss compared with bupropion-naltrexone was associated with an increased risk for pancreatitis, gastroparesis and bowel obstruction but not biliary disease, researchers reported in JAMA

Its cognitive-support properties have been extensively studied

Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed to maximize metabolic benefits with reduced side-effects, are in clinical trials to treat type 2 diabetes and obesity

1 (2025 ): 400- Glycated hemoglobin (HbA1c) remains the gold standard for assessing long-term glycemic control, reflecting the average plasma glucose over the preceding 812 weeks

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