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A gradual dose reduction under medical supervision allows the body to adjust and supports a safer transition

Limitations As a retrospective review of data from a single poison center, this study has several limitations

Nausea and vomiting force 70% of patients to stop treatment within a year

It's the intrusive thoughts about what to eat next, the preoccupation with snacks, cravings that interrupt concentration, the mental pull toward the kitchen that arrives even when you're not physically hungry

Lancet Diabetes Endocrinol 7(10):776785 Muskiet MHA, Smits MM, Morsink LM, Diamant M (2014) The gutrenal axis: do incretin-based agents confer renoprotection in diabetes

This happened at much higher non-physiologically relevant concentrations than that stimulated by glucagon previously demonstrated by Samols group (Samols, Marri, Marks, 1966)