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Diet-induced weight loss (WL) leads to increased hunger and reduced fullness feelings, increased ghrelin and reduced satiety peptides concentration (glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK) and peptide YY (PYY))

Recently compound 2 has been described as both an agonist and positive allosteric modulator of GLP-1 736 amide affinity, but not potency, at the GLP-1R
