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DPP-4 rapidly degrades incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are crucial for regulating glucose homeostasis
Immunoneutralizatrion of circulating plasma ghrelin with specific IgG anti-ghrelin antibodies, causes a marked increase in plasma leptin and decrease in food intake
Diet, exercise, and behavioral interventions have historically provided minimal and unsustained benefit, because they cannot fix a broken brain circuit
Romigi, M
J Clin Neurosci 95:172179
