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These data align with an integrated analysis of 36 clinical studies that affirmed cardiovascular safety with up to 4-years treatment with either DPP-4 inhibitors or GLP-1R agonists [655]
For this reason, the investigators modeled weight rebound on a continuous trajectory using available follow-up data from the included studies
Diabetes Res Clin Pract 222:112088 Paik JM, Tesfaye H, Curhan GC, Zakoul H, Wexler DJ, Patorno E (2024) Sodium-glucose cotransporter 2 inhibitors and nephrolithiasis risk in patients with type 2 diabetes
Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
The HormoneSynergy Perspective HormoneSynergy uses probiotic products as tools within a larger clinical plan
111 Although COCPs have been shown to alter metabolic parameters, there is ongoing research that continues to debate their impact on weight status
