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Similarly, the specific blocking of Gq signalling with YM254890 or transient receptor potential melastatin 5 (TRPM5) with triphenylphosphine oxide (TPPO) suppressed the triagonist-induced enhancement of GSIS
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To determine the changes in microglial activation, IL-1 and TNF- were examined by western blotting, and the number and morphology of microglia were measured by immunofluorescence
