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Exendin-4 therapy still offered an additional benefit on reducing transverse aortic constriction-induced cardiac hypertrophy-caused myocardial damage in DPP-4 deficient rats

References Nauck MA, Meier JJ

Its effects in vivo were therefore tested during insulin-induced hypoglycaemia (glucose lowered to ~3 mmol/l)

In practical terms, working with your clinician for treatments specific to you and your symptoms is important

By activating additional receptors, dual and triple agonists can tap into a broader set of levers at once, offering the chance for greater weight reduction, improved glycemic control, and (possibly) fewer side effects compared to GLP-1 monotherapy