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Proteins that were upregulated by GLP-1GIPLani (cluster 2) were enriched in functions related to cell division, DNA binding, transcriptional regulation and mRNA metabolism, whereas proteins that were downregulated by GLP-1GIPLani (cluster 4) were associated with mitochondrial inner membrane components, oxidative phosphorylation, tricarboxylic acid cycle, NAD-related processes and protein biosynthesis (Extended Data Fig