semaglutide 7.2 Once-weekly 7·2 mg in adults with obesity and type 2 diabetes (STEP UP T2D): a randomised, controlled, phase 3b trial FDA approves oral Semaglutide for

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Researchers have identified a specific group of brainstem neurons that mediate the appetite-reducing and weight-loss effects of semaglutide without triggering side effects like nausea.

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![Figure][1] Graphical Abstract: ### Competing Interest Statement The FR + FMG laboratory receives funding from AstraZeneca, Eli Lilly and LGM for unrelated research and FMG consults for Kallyope (New York)

A new study maps the intracellular cAMP signaling pathways of semaglutide, discovering an enzymatic method to extend GLP-1 weight-loss efficacy.