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Each subject received in a random order a single subcutaneous dose of 1.2 mg liraglutide and placebo at an interval of 48 h, with subsequent clinical follow-up in the metabolic ward, during which blood pressure was monitored for the following 24-h and 24 h urinary samples were collected to assess sodium excretion

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Given that there are central and peripheral distributions of ghrelin, several mechanisms have been proposed in which ghrelin will activate its receptor in the hypothalamus, including crossing the bloodbrain barrier, activating VANs, or synthesizing locally