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A larger evidence synthesis also supports Tirzepatide s strong efficacy while noting expected gastrointestinal side effects

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Sources Efficacy and safety of GLP-1 for weight management: evidence from the STEP program Effect of continued weekly subcutaneous GLP-1 vs placebo on weight loss maintenance in adults with overweight or obesity: the STEP 4 randomized clinical trial GLP-1 for the treatment of overweight and obesity: a review Efficacy and safety of liraglutide and GLP-1 on weight loss in people with obesity or overweight: A systematic review

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Apelin resistance contributes to muscle loss during cancer cachexia in mice

A 600-calorie shake is much easier to consume than a 600-calorie meal when appetite is low