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27 In the pancreas, GLP-1 receptor (GLP-1R) activation in islet cells promotes glucose-dependent insulin secretion from -cells, 28 inhibits glucagon release from -cells, and suppresses exocrine function via induction of pancreatic somatostatin

However, for diabetic patients, any foot pain should be taken seriously due to increased risks of complications like ulcers and infections

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The condition reduces the amount of blood that reaches leg muscles, making even a short trip to the mailbox painful and challenging

J Biol Chem 2010;285:1016-1022