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10.1002/cphy.c190025 Compr Physiol

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For many people, happiness about their breakthrough weight loss arrives mixed with something akin to grief

Another study showed that the impact of tirzepatide on weight loss was greater than semaglutide in adults who are overweight or obese, demonstrating different effects in comparison to the breast cancer population [90]

Once-daily liraglutide compared favorably with twice-daily exenatide, with similar improvements in A1C and body weight reductions

Disregarding differences due to experimental conditions including acute versus chronic intervention or animal species or strains, these data suggest that endogenous GLP-1R signaling in the brain may play a constitutive role in the homeostatic control of BAT thermogenesis, beyond its physiological modulation by brain-derived GLP-1