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RP-HPLC analysis showed synthesis-related impurities in compounded samples including close-eluting impurities near the main semaglutide peak that were absent or present at much lower levels in the pharmaceutical-grade recombinant product

Compounding is now limited to narrow, patient-specific medical needs, not cost or convenience

However, their benefits extend well beyond glucose lowering

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Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study