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a , steatosis grade, ( b ) lobular inflammation, ( c ) biliary hyperplasia and ( d ) hepatocyte ballooning

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13 , 15 Although the magnitude of this effect in clinical settings remains unclear, there is a biological rationale to consider an elevated risk of volume-related symptoms in susceptible individuals, such as older adults, those with orthostatic hypotension, or patients on multidrug antihypertensive regimens

Based on the number of FDA Adverse Events reports received for this unusual side effect, the FDA is monitoring all the GLP-1 drugs for possible regulatory action related to the side effect

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