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A new study by an international group of scientists, published in Cell Reports Medicine , tried to address the looming questions more rigorously

Individuals with higher levels of psychological distress may be more vulnerable to weight-related stigma or internalised weight bias [52], leading to greater concern about appearance and heightened motivation to seek pharmacological interventions

Adipose tissue, particularly visceral fat, is metabolically active and secretes pro-inflammatory adipokines

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What is also interesting is that the weight loss in the diabetic trial and non-diabetic trial of orforglipron were nearly identical at the top dose