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Effetti collaterali gastrointestinali: il problema pi rilevante La tossicit gastrointestinale rappresenta il principale limite alla tollerabilit dei GLP-1 RA

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Compared with the HF group, the HF+Lira group decreased serum AST, ALT, and TC, serum TG levels decreased significantly, the mRNA expression of SOCS-3 and SREBP-1c decreased significantly, and the liver TG level was also reduced

An important consideration when analyzing meal-induced GLP-1 secretion is whether GLP-1 was measured in systemic or portal vein blood, whether the samples were taken in relation to oral meals or rather to intragastric infusion of liquid (or semiliquid) meals, and whether total or active GLP-1 was measured

The resulting blood level fluctuations manifest as variable side effects

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