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Description
Comparison of CT-388 (Roche/Carmot) and tirzepatide (Mounjaro/Zepbound), two dual GLP-1/GIP agonists with different signaling profiles, weight loss data, and development status.
GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

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