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doi: 10.2215/CJN.11881019

For Hashimoto's patients, this discontinuation requires careful planning because: Thyroid hormone requirements increase significantly during pregnancy (typically 25-50% higher) Weight regain after GLP-1 discontinuation will change levothyroxine requirements again Optimal thyroid function before conception is critical for fetal brain development If you discover you are pregnant while on a GLP-1 medication , stop the medication immediately and contact your healthcare provider for urgent thyroid function testing and levothyroxine dose adjustment

The 12mg dose delivered the strongest 3-month results at 9.8% average weight loss

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Approved pharmaceutical formulations will become available through traditional medical channels, potentially reducing demand for research-grade products