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I get this question every week, and it matters because these are not all the same drug
Most healthcare providers start with 150 mg once daily, then may increase to 300 to 400 mg per day taken twice daily

however, since this work was done in vitro , it is most unlikely that the sDPP4-induced impairment of insulin action is due to an increased bioavailability of any DPP4 substrate

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