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In its fourth-quarter earnings call, Novo Nordisk estimated that about 50 million Americans with obesity now have access to Wegovy

Thus, the decreased cardiorenal risk associated with the combined use of GLP1-RAs/SGLTis may be attributed to an additive effect, achieved by the distinct mechanisms and sites of action for these different drug classes [13]

Regular monitoring and follow-up appointments are essential during treatment

Abbreviations BAT: Brown adipose tissue CEX: C-terminal extension CNS: Central nervous system DIO: Diet-induced obese DPP-IV: Dipeptidylpeptidase-IV EMA: European Medicines Agency FDA: Food and Drug Administration GcgR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GIPR: GIP receptor GLP-1: Glucagon-like peptide 1 GLP-1R: GLP-1 receptor OXM: Oxyntomodulin PEG: Polyethylene glycol STZ: Streptozotocin T 3 : Thyroid hormone References Obesity and overweight fact sheet

Since NAION cannot be reversed, it is crucial for anyone undergoing GLP-1 therapy to seek immediate medical attention if they notice any changes in their eyesight
It is often described as a triple-agonist due to its activity on GLP-1, GIP, and glucagon receptors