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Woo AYH, Xiao R
Experimental studies have also pointed to a direct ICP-lowering effect of GLP-1RAs
In contrast, preoperative GLP-2 plasma concentrations did not differ, but increased 3.4-fold within the first postoperative day in patients with PHLF, compared to an 1.5-times increase in patients who did not develop PHLF, resulting in 2.0-times higher GLP-2 level in PHLF on POD1 ( p = 0.008)
10.1016/j.kint.2020.08.037 [DOI] [PubMed] [Google Scholar] 28
2) the intervention consisted of administration of a GLP-1 receptor agonist
As such, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) critically affect hepatic regeneration in rodent models
