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2026

Its a critical tool for decision-making and patient-centered dialogues

In animal studies, GLP-1 agonists triggered anxiety early in treatment which then subsided and shifted toward reduced depression-like behaviour with continued use

Dual- and triple action approaches which simultaneously target multiple pathways, for example, GLP1R/GIP (tirzepatide), GLP1R/GIP/glucagon (retatrutide) or amylin/GLP1R (CagriSemra) appear more potent and may push weight reduction to the mid-20% range and possibly beyond, while oral options seek to deliver levels of efficacy seen with injectables

Injection-site reactions and worsening of pre-existing diabetic retinopathy are also relevant clinical concerns

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