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Mouse studies showed no observable adverse effects at the doses used

At 26 weeks, changes in apoC-III, rather than body weight, were the most accurate predictors of changes in triglyceride levels with tirzepatide, accounting for up to 22.9% of the variability observed.Treatment with tirzepatide demonstrated a dose-dependent decrease in apoC-III and apoB levels, as well as a reduction in the number of large TRLP and small LDLP
RI-S: Writing original draft

Endocrine implications of bariatric surgery: a review on the intersection between incretins, bone, and sex hormones

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